Analysis of HBGA-binding interfaces and the surrounding region for representative GII.4 strains.

<p>Ten representative sequences were selected from each major phylogenetic cluster from 1974 to 2012. The P domain sequences were aligned using MegAlign. Amino acids in green indicate residues that are required for HBGA binding. Light blue residues indicate amino acids that affect the binding specificity. Red letters indicate differences from the consensus sequence within the binding interfaces or surrounding regions. The percent similarity between all 82 strains is indicated at the bottom for key amino acids involved in HBGA binding.