Effect of Pgp5 deficiency on the development of hydrosalpinx following <i>C</i>. <i>muridarum</i> infection.

<p>The wild type (wt) <i>C</i>. <i>muridarum</i> (CM, panel a), plasmid-free (pf) CMUT3 (b) or CMUT3 transformants (CM-pGFP::CM, panel c; CM-pgp5S, d; CM-Δpgp5, e; CM-Δpgp7, f) were used to intravaginally infect C3H/HeJ mice with an infection dose of 2x10⁵ IFUs. Sixty days after infection, all mice were sacrificed for observing gross appearance of the upper genital tracts. One representative image of the entire genital tract from each group is presented with the vagina/cervix at the left and the oviduct/ovary at the right sides. The total number of mice (n), the incidence (%) and severity (x ± SD) of hydrosalpinges in each group are listed under the corresponding image. Note that the CM(wt) and CM-pGFP::CM induced high incidence of severe hydrosalpinx while the mice infected by CM-pgp5S, CM-Δpgp5 or CMUT3 displayed significant reduced hydrosalpinx. ^&P<0.05 or ^&&P<0.01 (Fisher’s Exact); *P<0.05, **P<0.01 (Wilcoxon rank-sum).