Intramyocardial WDR12 gene delivery deteriorates cardiac function in normal adult rat.

<p>Adenoviral construct expressing WDR12 and LacZ were injected into LV free wall. Echocardiographic measurements were performed 1 week after gene transfer. <b>A</b>. Representative M-mode images are shown. Treatment with WDR12 overexpressing vector significantly decreased interventricular septum diastolic (<b>B</b>) and systolic thickness (<b>C</b>), and increased LV diastolic (<b>D</b>) and systolic diameters (<b>E</b>). Overexpression of WDR12 decreased LV ejection fraction (<b>F</b>) and fractional shortening (<b>G</b>). The results are expressed as mean±SEM (n = 7 to 10). *<i>P</i><0.05, **<i>P</i><0.01 versus LacZ-control group (Student <i>t</i> test).