A schematic presentation of WDR12 in the heart.
- Anne-Mari Moilanen (314843)
- Jaana Rysä (314845)
- Leena Kaikkonen (618018)
- Teemu Karvonen (730827)
- Erja Mustonen (314847)
- Raisa Serpi (314846)
- Zoltán Szabó (211818)
- Olli Tenhunen (314852)
- Zsolt Bagyura (545482)
- Juha Näpänkangas (314850)
- Pauli Ohukainen (730828)
- Pasi Tavi (231574)
- Risto Kerkelä (545912)
- Margrét Leósdóttir (730829)
- Björn Wahlstrand (238571)
- Thomas Hedner (238566)
- Olle Melander (25955)
- Heikki Ruskoaho (314854)
Publication date
April 2015
DOIAbstract
<p>Our results suggest that in MI increased LV wall tension induces up-regulation of WDR12 expression via direct myocyte stretch and activation of p38 MAPK pathway. WDR12 gene delivery activated BOP1 and p38 MAPK/HSP27 pathways, leading to decreased cell proliferation and pro-fibrosis, thinning of the LV wall and dilatation of the LV, and myocardial dysfunction.</p
Add to ORKG