Confidence interval coverage rate of the allele effect in people without a moderator (<i>β</i>₁) and people with a moderator (<i>β</i>₁ + <i>β</i>₃) in individual patient data regression analysis.

<p>The model names, “Basic,” “Minor rare,” “Serious rare,” “Minor independence,” and “Serious independence” indicate the models, “Basic,” “Minor violation of rare disease assumption,” “Serious violation of rare disease assumption,” “Minor violation of independence assumption,” and “Serious violation of independence assumption,” respectively. <i>F</i>_st is the parameter of frequency difference among various studies. The X-axis represents the confidence interval of the moderator effect (<i>β</i>₃); the Y-axis represents the 95% confidence interval coverage rate. The red bar represents the 95% confidence interval coverage rate of the allele effect in people without a moderator (<i>β</i>₁); the blue bar represents the 95% confidence interval coverage rate of the allele effect in people with a moderator (<i>β</i>₁ + <i>β</i>₃).