Effect of repeated neonatal isoflurane exposure on behavioral testing.

<p>(A) Mice that received repeated neonatal exposure to 0.75% isoflurane displayed normal traveled total distance in Open-field tests. (B) Mice that received repeated neonatal exposure to 0.75% isoflurane displayed normal affective state(anxiety level), which was measured by the percentage of time spent in the center of open-field. (C) Mice that received repeated neonatal exposure to 0.75% isoflurane displayed decreased freezing time (** p<0.01 versus control) during contexual fear conditioning (CFC) test. The control group inhaled 30% O₂-enriched air during the neonatal period.