<p>Urine protein analysis by SDS-PAGE from urine samples of PCK rats after 6 weeks of treatment with vehicle (CON) or dapagliflozin (DAPA). Each lane shows urine sample of a single PCK rat. Sample volumes were corrected for diuresis and amounted to 15 μl for CON and 45 μl for DAPA. Arrow shows the band for albumin. M = molecular weight marker (A). Urine albumin concentration as measured by ELISA, in mg/day (B). N = 8 per group. Columns represent means ± SE. **<i>P</i><0.01, ***<i>P</i><0.001 when comparing CON and DAPA at each time point, ns = non-significant.</p
<p>Representative areas of Ki67 immunohistochemical staining in PCK rat kidneys are shown. Nuclei of...
BACKGROUND: Reductions in albuminuria are associated with a subsequent lower risk of kidney failure ...
<p><i>db/m</i>, nondiabetic control mice; <i>db/db</i>, untreated diabetic mice; <i>db/db</i>+0.1 da...
<p>Data are expressed as means ± SE. CON, vehicle control; DAPA, dapagliflozin.</p><p>*<i>P</i><0.05...
<p>Data are expressed as means ± SE. CON, vehicle control; DAPA, dapagliflozin.</p><p>*<i>P</i><0.05...
<p>Analysis of cAMP concentration per mg protein in PCK rat kidneys treated with vehicle (CON) or da...
<p>Data are expressed as means ± SE. CON, vehicle control; DAPA, dapagliflozin.</p><p>*<i>P</i><0.05...
<p>Representative renal histology by periodic acid-Schiff (PAS) staining of kidneys in vehicle- trea...
<p>Ratio of two kidney weights to total body weight (2KW/TBW) (A), cyst index (B) and number of cyst...
<p>Morphometric analysis using Ki67, a proliferation marker in kidney medulla of vehicle (CON)- and ...
<p>Proteinuria (A), albuminuria (B), <i>N</i>-acetyl-<i>β</i>-D-glucosaminidase (C) and neutrophil g...
<p><b>(A)</b> Representative size exclusion profile of [<sup>14</sup>C]RSA in urine (<i>closed squar...
Proteinuria develops rapidly after the induction of experimental diabetes and is the major abnormali...
<p>After four weeks of MS05 treatment (n = 17), the urinary albumin- to-creatinine ratio (UACR) was ...
<p>Albuminuria, expressed as mean ± SEM, developed in untreated diabetic animals during the course o...
<p>Representative areas of Ki67 immunohistochemical staining in PCK rat kidneys are shown. Nuclei of...
BACKGROUND: Reductions in albuminuria are associated with a subsequent lower risk of kidney failure ...
<p><i>db/m</i>, nondiabetic control mice; <i>db/db</i>, untreated diabetic mice; <i>db/db</i>+0.1 da...
<p>Data are expressed as means ± SE. CON, vehicle control; DAPA, dapagliflozin.</p><p>*<i>P</i><0.05...
<p>Data are expressed as means ± SE. CON, vehicle control; DAPA, dapagliflozin.</p><p>*<i>P</i><0.05...
<p>Analysis of cAMP concentration per mg protein in PCK rat kidneys treated with vehicle (CON) or da...
<p>Data are expressed as means ± SE. CON, vehicle control; DAPA, dapagliflozin.</p><p>*<i>P</i><0.05...
<p>Representative renal histology by periodic acid-Schiff (PAS) staining of kidneys in vehicle- trea...
<p>Ratio of two kidney weights to total body weight (2KW/TBW) (A), cyst index (B) and number of cyst...
<p>Morphometric analysis using Ki67, a proliferation marker in kidney medulla of vehicle (CON)- and ...
<p>Proteinuria (A), albuminuria (B), <i>N</i>-acetyl-<i>β</i>-D-glucosaminidase (C) and neutrophil g...
<p><b>(A)</b> Representative size exclusion profile of [<sup>14</sup>C]RSA in urine (<i>closed squar...
Proteinuria develops rapidly after the induction of experimental diabetes and is the major abnormali...
<p>After four weeks of MS05 treatment (n = 17), the urinary albumin- to-creatinine ratio (UACR) was ...
<p>Albuminuria, expressed as mean ± SEM, developed in untreated diabetic animals during the course o...
<p>Representative areas of Ki67 immunohistochemical staining in PCK rat kidneys are shown. Nuclei of...
BACKGROUND: Reductions in albuminuria are associated with a subsequent lower risk of kidney failure ...
<p><i>db/m</i>, nondiabetic control mice; <i>db/db</i>, untreated diabetic mice; <i>db/db</i>+0.1 da...