Circular Bigraphs (CBG) in phenome-genome association network.

<p>A circular bigraph is composed of a phenotype path and a gene path with two ends connected by phenotype-gene associations. (A), (B) and (C) CBGs with phenotype or gene paths of length 1, 2 and 3. CBGs of length 1 represent the simple hypothesis. (D) The general hypothesis that CBG with phenotype or gene paths of arbitrary length. The blue bar on the right of the figures reports the percentage of OMIM disease phenotype-gene associations that are covered by CBGs up to a certain path length. The red bar reports the percentage in the MGI mouse phenotype-gene associations.