<p><b>A</b>. Cell viability test of 3D spheres carrying gene knockdowns under long-term (7d) hypoxia. Viable cells = ‘green’, dead cells = ‘red’. Representative images are shown (n = 10). <b>B</b>. Quantification of the percentage of dead cells within 3D spheres in hypoxia (n = 10; mean ± SEM) (* p<0.05; ** p<0.01; *** p<0.001).</p
Background. Glioblastoma multiforme (GBM) develops in the hypoxic microenvironment, which plays an i...
ii Glioblastomas are aggressive, lethal primary brain tumors that affect human and canine patients. ...
<p>(A) The graded chronic hypoxia (GCH) protocol is shown, depicting the timing and severity of hypo...
licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...
<p><b>A</b>. Stem-like (NCH644, NCH421k) and classical adherent (U87, U251) glioma cells were cultur...
Glioblastoma multiforme (GBM) constitute over 50 % of primary brain tumors in adults. The tumor is h...
Hypoxia is associated with the increased malignancy of a broad range of solid tumours. While very se...
<p>(<b>A</b>) Glycogen levels in astrocytes treated with either DAB (1 mM) or CP-316819 (10 µM) or D...
Glioblastoma is the most common and malignant brain cancer. In spite of surgical removal, radiation ...
<p>(A) To assess cell death in vitro, microglia with the treatment for the indicated time were subje...
<p>A, U87 MG cells were grown at normoxic (N, 21% O<sub>2</sub>) or hypoxic (H, 1% O<sub>2</sub>) co...
Objectives: The lack of oxygen in regions of many solid tumours has been shown to promote metastasi...
<p>Hu-glioma cells, Rt-glioma cells and Ms-NSCs were cultured under normoxic conditions and subjecte...
<p>a-h) GSCs were deprived from mitogens for 1 to 3 days. GSCs growing in mitogen-supplemented mediu...
<p>Images of calcein (live) and ethidium (dead) cells labeled OLs cultured in the presence or absenc...
Background. Glioblastoma multiforme (GBM) develops in the hypoxic microenvironment, which plays an i...
ii Glioblastomas are aggressive, lethal primary brain tumors that affect human and canine patients. ...
<p>(A) The graded chronic hypoxia (GCH) protocol is shown, depicting the timing and severity of hypo...
licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...
<p><b>A</b>. Stem-like (NCH644, NCH421k) and classical adherent (U87, U251) glioma cells were cultur...
Glioblastoma multiforme (GBM) constitute over 50 % of primary brain tumors in adults. The tumor is h...
Hypoxia is associated with the increased malignancy of a broad range of solid tumours. While very se...
<p>(<b>A</b>) Glycogen levels in astrocytes treated with either DAB (1 mM) or CP-316819 (10 µM) or D...
Glioblastoma is the most common and malignant brain cancer. In spite of surgical removal, radiation ...
<p>(A) To assess cell death in vitro, microglia with the treatment for the indicated time were subje...
<p>A, U87 MG cells were grown at normoxic (N, 21% O<sub>2</sub>) or hypoxic (H, 1% O<sub>2</sub>) co...
Objectives: The lack of oxygen in regions of many solid tumours has been shown to promote metastasi...
<p>Hu-glioma cells, Rt-glioma cells and Ms-NSCs were cultured under normoxic conditions and subjecte...
<p>a-h) GSCs were deprived from mitogens for 1 to 3 days. GSCs growing in mitogen-supplemented mediu...
<p>Images of calcein (live) and ethidium (dead) cells labeled OLs cultured in the presence or absenc...
Background. Glioblastoma multiforme (GBM) develops in the hypoxic microenvironment, which plays an i...
ii Glioblastomas are aggressive, lethal primary brain tumors that affect human and canine patients. ...
<p>(A) The graded chronic hypoxia (GCH) protocol is shown, depicting the timing and severity of hypo...