Gene expression of cDCs upon stimulation with virus or vaccine preparations.

<p>Murine cDCs were cultured and stimulated as described in the legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125228#pone.0125228.g001" target="_blank">Fig 1</a>. RNA was isolated from the DCs and gene expression was measured by Affymetrix mouse 430 2.0 Genechip array. Two biological replicates per experimental condition were used. Genes were selected that were significantly (p<0.05) regulated compared to the time-matched medium control sample in at least one of the treatment groups at at least one of the sampling moments. This resulted in the inclusion of a total of 4812 genes into further analyses. A heatmap of all differentially regulated genes is shown, where upregulated genes are depicted in red and downregulated genes are depicted in green.