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Proposed mechanism of action of pentacyclic triterpenoids on LPS induced NF-κB signaling.

Kalpesh R. Patil (734319)
Purusottam Mohapatra (734320)
Harun M. Patel (734321)
Sameer N. Goyal (654407)
Shreesh Ojha (654405)
Chanakya N. Kundu (590075)
Chandragouda R. Patil (734322)

Publication date

May 2015

DOI

10.1371/journal.pone.0125709.g009

Abstract

<p>Abrogation of NF-κB activation by pentacyclic triterpenoids may be resulted due to down regulated IKKβ phosphorylation.</p

Extracted data

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Harun M. Patel
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Zhang, Hui-xing
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Bao, Yong-rui
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Dinkova-Kostova, Albena T.
Liby, Karen T.
Stephenson, Katherine K.
Holtzclaw, W. David
Gao, Xiangqun
Suh, Nanjoo
Williams, Charlotte
Risingsong, Renee
Honda, Tadashi
Gribble, Gordon W.
Sporn, Michael B.
Talalay, Paul

March 2005

THE SPECIAL CHARACTERS IN THIS ABSTRACT CANNOT BE DISPLAYED CORRECTLY ON THIS PAGE. PLEASE REFER TO ...

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

E. Goldring
Albena T. Dinkova-kostova
Tadashi Honda
B. Kevin Park

January 2014

The transcription factor Nrf2 protects against a number of ex-perimental pathologies, and is a promi...

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Suman Dalal (497983)
Barbara Connelly (5154839)
Mahipal Singh (497984)
Krishna Singh (306728)

April 2018

<p>β-AR-stimulation using isoproterenol increases phosphorylation and sumoylation of NF2. This pathw...

Is a phenylalanine-glucosamine derivative able to affect the main responsible for IκB protein phosphorylation?

Bigioni I
Mariano A
Scotto D'Abusco A

January 2022

Nuclear factor κB (NFkB) is an ubiquitous transcription factor well known for its role in the innate...

LPS-induced NF-κB activation alleviates the protective roles of ginsenoside Rb3.

Lijia Ma (225644)
Huimin Liu (284624)
Zulong Xie (607379)
Shuang Yang (64650)
Wei Xu (28953)
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Triterpenic acids are a widespread class of phytocompounds which have been found to possess valuable...