We examined heterozygous transgenic (Tg) mice that overexpress V717F amyloid precursor protein (APP) for delay eyeblink conditioning (EBC) and hippocampal volume with magnetic resonance imaging (MRI). Platelet-derived APP mice were significantly impaired on EBC relative to wild type (WT) litter-mate controls. T2-weighted spin echo images (62.5 x 125 x 500 mum) of the same mice were acquired under anesthesia using a 9.4T magnet. Tg mice had hippocampal to brain volume ratios that were significantly smaller than WT controls (31% smaller in the rostral dorsal hippocampus, 13-22% smaller among equal dorsal-ventral thirds of a caudal section). These results indicate that overexpression of APP or beta amyloid profoundly affects learning and memor...
The behavioral and biochemical impact of active immunization against human beta-amyloid (Abeta) was ...
Multiple animal models have been created to gain insight into Alzheimer's disease (AD) pathology. Am...
The cerebral deposition of amyloid -peptide, a central event in Alzheimer’s disease (AD) pathogenesi...
Amyloid pathology occurs early in Alzheimer's disease (AD), and has therefore been the focus of nume...
High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric ...
Nonphysiologic overexpression of amyloid-β (Aβ) precursor protein in common transgenic Aβ mouse mode...
Alzheimer’s disease is a neurodegenerative disease that has many pathological features including; pl...
Ziel/Aim: Overexpression of ß-amyloid (Aß) precursor protein in common transgenic Aß mouse models of...
Amyloid-β (Aβ) peptides occur in the brains of patients with Alzheimer's disease (AD), but their rol...
Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder and has been rec...
Abstract Amyloid pathology occurs early in Alzheimer's disease (AD), and has therefore been the foc...
Mutations in the amyloid precursor protein (APP) gene inducing abnormal processing and deposition of...
<p>Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and...
<p>Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and...
<p>Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and...
The behavioral and biochemical impact of active immunization against human beta-amyloid (Abeta) was ...
Multiple animal models have been created to gain insight into Alzheimer's disease (AD) pathology. Am...
The cerebral deposition of amyloid -peptide, a central event in Alzheimer’s disease (AD) pathogenesi...
Amyloid pathology occurs early in Alzheimer's disease (AD), and has therefore been the focus of nume...
High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric ...
Nonphysiologic overexpression of amyloid-β (Aβ) precursor protein in common transgenic Aβ mouse mode...
Alzheimer’s disease is a neurodegenerative disease that has many pathological features including; pl...
Ziel/Aim: Overexpression of ß-amyloid (Aß) precursor protein in common transgenic Aß mouse models of...
Amyloid-β (Aβ) peptides occur in the brains of patients with Alzheimer's disease (AD), but their rol...
Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder and has been rec...
Abstract Amyloid pathology occurs early in Alzheimer's disease (AD), and has therefore been the foc...
Mutations in the amyloid precursor protein (APP) gene inducing abnormal processing and deposition of...
<p>Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and...
<p>Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and...
<p>Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and...
The behavioral and biochemical impact of active immunization against human beta-amyloid (Abeta) was ...
Multiple animal models have been created to gain insight into Alzheimer's disease (AD) pathology. Am...
The cerebral deposition of amyloid -peptide, a central event in Alzheimer’s disease (AD) pathogenesi...