Adjusted Relative Hazard of Outcomes in 394 Incident Hemodialysis Patients of the CHOICE Study.

<p><b>Panel 2A:</b> Adjusted hazard of Cardiovascular Mortality. <b>Panel 2B:</b> Adjusted hazard of First Cardiovascular Event. Relative hazard predicted using Cox proportional hazards regression adjusted for demographics (age, sex and race), clinical characteristics [body mass index, residual kidney function (self-reported ability to produce >1 cup of urine daily), Index of Coexistent Disease (ICED) score, diabetes and cardiovascular disease] and laboratory tests (Kt/V_UREA, albumin, phosphate and creatinine). Solutes and combined solute index are modeled as restricted cubic splines with knots at the 10th, 50th, and 90th percentiles. The solid line is the adjusted HR; 10th percentile is used as the reference (HR = 1). The shaded area is the 95% CI of the HR. Bars are the frequency histogram, showing the distribution of each solute and combined solute index. Vertical broken lines mark the 25^th and 75^th percentile of the distribution.