Evolutionary histories vary across the OAS gene family in primates.

<p>Phylogenetic analyses of OAS1, OAS2, OAS3, and OASL were carried out using sequences from 11 matching primate species. <b>(A)</b> Gene structures of the OAS gene family members in primates. NTase (red) and OAS1-C (gray) domains are indicated. For OASL the ubiquitin-like domains (yellow) are also indicated. Amino acid sites with statistically significant ω values obtained from NSsites (PAML [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005203#pgen.1005203.ref044" target="_blank">44</a>]), FUBAR, and MEME (HyPhy [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005203#pgen.1005203.ref045" target="_blank">45</a>]) are indicated above the gene. <b>(B)</b> Primate species trees with ω values obtained from free-ratio analyses in PAML [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005203#pgen.1005203.ref044" target="_blank">44</a>] for each lineage. dN/dS values and lineages with ω > 1 or at least 3 nonsynonymous:0 synonymous amino acid substitutions are highlighted in red.