<p>Mouse liver samples were collected at day 10 after HI with pBS-WHV1.3 (WHV1.3), pWHV-HBV-Sa (Sa), pWHV-HBV-SS (SS), pWHV-HBV-MS (MS) and saline (Mock). The replication intermediates were detected by Southern blot using a full length WHV genome as probe. The signal intensity was quantified by measuring the grey scale using WHV1.3 as the reference. RC DNA: relaxed circular DNA; SS DNA: single stranded DNA.</p
In the hydrodynamic injection (HI) BALB/c mouse model with the overlength viral genome, we have foun...
<p>10 µg of pAAV-HBV-B alone or combined with 20 µg pmIFN-α were used for HI. (A) HBsAg and HBeAg le...
A reverse transcription and polymerase chain reaction method was developed and used to detect fecal ...
<p>Nine BLAB/c mice (W1.3–1 to 9) were hydrodynamically injected with pBS-WHV1.3. (A) Mouse sera wer...
<p>(A) Six mice (Sa1-Sa6) were hydrodynamically injected with pWHV-HBV-Sa, while four mice (H1.3–1 t...
<p>(a) Detection of HBV DNA replicative intermediates 7 days post pSSV9-1.2HBV transfected to Huh7.5...
<p>BALB/c (A), C57BL/6 (B), and FVB/N (C) mice were hydrodynamically injected with 10 µg of the pHBV...
<p>(A) Schema of the treatment. The mice were treated with saline (Saline) or CsA from 1 week before...
<p>(A) DNA (Southern) filter hybridization analysis of representative mice of each sex and genotype ...
<p>Southern blot analysis was performed on the DNA obtained from the liver samples collected post-mo...
<p>(<b>A</b>) A2/NSG/Fas-hu mice or non-humanized mice were inoculated with PBS or HBV (1×10e3, 10e5...
<p>(A) Mouse sera were collected after HI with pWHV-HBV-SS (SS) and pWHV-HBV-MS (MS) at the indicate...
<p>(A) The schematic map of recombinant WHV-HBV genomes. pBS-WHV1.3 contained a 1.3 fold overlength ...
<div><p>Hydrodynamic injection (HI) with a replication competent hepatitis B virus (HBV) genome may ...
Hepatitis B Virus (HBV) persists in infected hepatocytes as an episomal covalently-closed-circular D...
In the hydrodynamic injection (HI) BALB/c mouse model with the overlength viral genome, we have foun...
<p>10 µg of pAAV-HBV-B alone or combined with 20 µg pmIFN-α were used for HI. (A) HBsAg and HBeAg le...
A reverse transcription and polymerase chain reaction method was developed and used to detect fecal ...
<p>Nine BLAB/c mice (W1.3–1 to 9) were hydrodynamically injected with pBS-WHV1.3. (A) Mouse sera wer...
<p>(A) Six mice (Sa1-Sa6) were hydrodynamically injected with pWHV-HBV-Sa, while four mice (H1.3–1 t...
<p>(a) Detection of HBV DNA replicative intermediates 7 days post pSSV9-1.2HBV transfected to Huh7.5...
<p>BALB/c (A), C57BL/6 (B), and FVB/N (C) mice were hydrodynamically injected with 10 µg of the pHBV...
<p>(A) Schema of the treatment. The mice were treated with saline (Saline) or CsA from 1 week before...
<p>(A) DNA (Southern) filter hybridization analysis of representative mice of each sex and genotype ...
<p>Southern blot analysis was performed on the DNA obtained from the liver samples collected post-mo...
<p>(<b>A</b>) A2/NSG/Fas-hu mice or non-humanized mice were inoculated with PBS or HBV (1×10e3, 10e5...
<p>(A) Mouse sera were collected after HI with pWHV-HBV-SS (SS) and pWHV-HBV-MS (MS) at the indicate...
<p>(A) The schematic map of recombinant WHV-HBV genomes. pBS-WHV1.3 contained a 1.3 fold overlength ...
<div><p>Hydrodynamic injection (HI) with a replication competent hepatitis B virus (HBV) genome may ...
Hepatitis B Virus (HBV) persists in infected hepatocytes as an episomal covalently-closed-circular D...
In the hydrodynamic injection (HI) BALB/c mouse model with the overlength viral genome, we have foun...
<p>10 µg of pAAV-HBV-B alone or combined with 20 µg pmIFN-α were used for HI. (A) HBsAg and HBeAg le...
A reverse transcription and polymerase chain reaction method was developed and used to detect fecal ...