The growth of MDA-231 cells was significantly attenuated by co-culture with FST-hUCMSC (A), the conditioned medium from FST-hUCMSC (B), or by direct over-expression of FST (C).

<p>A, MDA-231 cells were co-cultured with either LacZ-, ADRP- or FST-hUCMSC for 48 hours. Cell growth was measured by MTT assay (panels A and B). Transduction of hUCMSC with adenoviral vector did not affect the cell growth. FST-hUCMSC, but not ADRP-hUCMSC significantly attenuated the growth of co-cultured carcinoma cells to the same level of MDA-231 cells cultured alone. B, the growth of MDA-231 cells was significantly attenuated by culturing with the conditioned medium (CM) from Ad-FST but not-LacZ or-ADRP transduced human UCMSC or defined medium (DM). C, the growth of MDA-231 cells was significantly attenuated by the direct transduction of Ad-FST but not by-LacZ or-ADRP. The colony growth rate of the FST-transduced MDA-231 cells from Day 7 to 12 was 1.02 (no growth), while the other gene-transduced cells colonies grew approximately 1.5 times bigger on Day 12 compared to Day 7. * <i>p</i> < 0.05.