Effect of polydatin on the mRNA expression of PPARβ, eNOS and iNOS under HG (glucose at 55 mmol/L) conditions.

<p>Co-incubation with polydatin (1, 3, or 10 μmol/L) in HG-stimulated aortas markedly upregulated the decreased <i>PPARβ</i> and <i>eNOS</i> mRNA levels, and reduced the <i>iNOS</i> level in a dose-dependent manner. GSK0660 (1 μmol/L) or <i>L</i>-NAME (10 μmol/L) blocked the effects of polydatin (3 μmol/L). (mean ± S.E.M, n = 3). * <i>P</i><0.05, ** <i>P</i><0.01 <i>vs</i>. NG (glucose at 11 mmol/L). ^#<i>P</i><0.05, ^##<i>P</i><0.01 <i>vs</i>. HG. ^Δ<i>P</i><0.05, ^ΔΔ<i>P</i><0.01 <i>vs</i>. HG+polydatin (3 μmol/L). “+” or “-”: treatment with or without the relevant reagent.