IL-11 treatment attenuated liver injury induced by IR.

<p>Mice were administered with recombinant human IL-IL-11 (500μg/kg, ip) or medium (PBS) 1 hour prior to ischemia, followed by 6h reperfusion. (A) sALT. (B) Histopathalogic analysis of livers harvested 6 hours after reperfusion. Sham group: Normal hepatic architecture; IR group: severe hepatic lobule distortion, sinusoidal congestion, apparent edema, vacuolization and massive necrosis; IL-11+IR group: mild vacuolization, punctate necrosis and edeman. (C) The severity of liver IRI by Suzuki’s histological grading. Data are expressed as mean±SD (n = 6/group), **P<0.001.