CXCR3 expression delineates a functionally fit subpopulation of ICOS<sup>+</sup> T<sub>reg</sub> cells.
- Mara Kornete (159481)
- Edward S. Mason (735813)
- Julien Girouard (735814)
- Erin I. Lafferty (373838)
- Salman Qureshi (407124)
- Ciriaco A. Piccirillo (159498)
DOIAbstract
<p>(A) Cell suspensions of pancreatic draining LN from 4-week-old mice were isolated and percent cycle cells, determined by Ki-67 expression, were compared between the CXCR3<sup><b>+</b></sup> and CXCR3<sup><b>-</b></sup> subsets of ICOS<sup><b>+</b></sup> T<sub><b>reg</b></sub> cells. (B) NOD.TCRα<sup><b>-/-</b></sup> mice received T<sub><b>eff</b></sub> (7.5X10<sup><b>5</b></sup>) cells and either CXCR3<sup><b>+</b></sup> or CXCR3<sup><b>-</b></sup> ICOS<sup><b>+</b></sup> T<sub><b>reg</b></sub> cells (7.5X10<sup><b>4</b></sup>) cells isolated from pooled LN and spleen of BDC2.5 mice. After 14 days suppression was assessed via percent IFN-γ<sup><b>+</b></sup> cells among T<sub><b>eff</b></sub> cells in the pancreas and draining LN. (n = 4...
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