Histopathology and bacterial loads in wild-type and IL-36R deficient mice.

<p>Hematoxylin eosin staining of lung sections 4 weeks after <i>M</i>. <i>bovis</i> BCG infection of WT (left panels) and IL-36R deficient (right panels) mice (original magnifications X2, upper panel, and X40, lower panel) (A). Determination of free alveolar space on lung sections. Data are represented as the mean ± SD of percentage of lung lesion free/total lung tissue in 5 mice per group with 1 or 2 lobes analyzed per mouse (B). Lung bacterial loads at 4 weeks post-infection are represented as CFU per lung (n = 6 mice per group) (C). **P<0.01 as assessed by Mann Whitney test.