Doxorubicin stimulates apoptosis and modulates IGF-1R/IGFBP-3 expression in H9c2 cells.
- Patrizia Fabbi (305756)
- Paolo Spallarossa (305753)
- Silvano Garibaldi (305755)
- Chiara Barisione (305754)
- Marzia Mura (115161)
- Paola Altieri (305752)
- Barbara Rebesco (2211460)
- Maria Gaia Monti (2211457)
- Marco Canepa (358617)
- Giorgio Ghigliotti (305757)
- Claudio Brunelli (305758)
- Pietro Ameri (696679)
Publication date
May 2015
DOIAbstract
<p>Frequency of apoptotic cells (A) and IGF-1R (B) and IGFBP-3 (C) expression (densitometry of western blot bands) 24 hours after no treatment (Ctr) or incubation of H9c2 cardiomyocytes with 0.1, 0.5, or 1 μM doxorubicin (Dox). A representative western blot for IGF-1R and IGFBP-3 is shown in (D). *, P <0.05 vs. Ctr; **, P <0.01 vs. Ctr; ***, P <0.001 vs. Ctr. a, P <0.01 vs. Dox 0.5; b, P <0.05 vs. Dox 0.1; c, P <0.001 vs. Dox 0.1.</p
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