<p>The diameter of each pie is scaled according to the magnitude (geometric mean). The pie charts represent <b>A.</b> CD40L+ CD4+ T cells expressing one, two or three cytokines to F4 (p24-RT-Nef- p17) peptide pools across groups A-D; <b>B.</b> CD40L+ CD4+ T cells expressing one, two or three cytokines to GRIN (Gag-RT-Int-Nef) peptide pools across groups A-D CD8+ T cells expressing one, two or three cytokines to GRIN (Gag-RT-Int-Nef) peptides pools across groups A-D and <b>C.</b> CD8+ T cells expressing one, two or three cytokines to GRIN (Gag-RT-Int-Nef) peptides pools across groups A-D. M: Months, Pre: pre-vaccination.</p
<p>Splenocytes from mice immunized as in <a href="http://www.plosone.org/article/info:doi/10.1371/jo...
<p><b>A.</b> Distribution of cytokines produced by multifunctional or monofunctional T cells. The pe...
<p>(A) The total magnitude of the PBMC CD8 T cell response as measured by IFN-γ ELISPOT assays using...
<p>The y-axis shows the magnitude of CD4+ and CD8+T-cells on a half-log scale across groups A-D for ...
<p>Pie charts show the qualitative composition of total gag-specific CD4+ or CD8+ T cell response; e...
<p>Pie charts show the qualitative composition of total gag-specific CD4+ or CD8+ T cell response; e...
<p>The magnitude of the CD4+ T cells expressing CD40L and at least one cytokine among IL-2, TNF-α an...
<p>The multi-functional composition of the CD4<sup>+</sup> T cell response (measured in <a href="htt...
<p>The magnitude of the CD8+ T cells expressing at least one cytokine among IL-2, TNF-α and IFN-γ is...
<p>Cells from each animal were stimulated with each different peptide pool for 6°C in the presence o...
<p>A. Geometric mean CS-specific CD4<sup>+</sup> T cells producing IFN-γ by ELISpot. Comparisons bet...
<p>The response patterns are color-coded by the number of positive functions. The x-axis contains th...
<p>PBMC from all study subjects were stimulated with peptide pools, selected for positive responses ...
<p>(<b>A</b>) Representative dot plots of gating strategy used and cytokine responses detected using...
<p>PBMCs isolated 2 weeks after the fourth immunization were stimulated <i>in vitro</i> with a SIVpo...
<p>Splenocytes from mice immunized as in <a href="http://www.plosone.org/article/info:doi/10.1371/jo...
<p><b>A.</b> Distribution of cytokines produced by multifunctional or monofunctional T cells. The pe...
<p>(A) The total magnitude of the PBMC CD8 T cell response as measured by IFN-γ ELISPOT assays using...
<p>The y-axis shows the magnitude of CD4+ and CD8+T-cells on a half-log scale across groups A-D for ...
<p>Pie charts show the qualitative composition of total gag-specific CD4+ or CD8+ T cell response; e...
<p>Pie charts show the qualitative composition of total gag-specific CD4+ or CD8+ T cell response; e...
<p>The magnitude of the CD4+ T cells expressing CD40L and at least one cytokine among IL-2, TNF-α an...
<p>The multi-functional composition of the CD4<sup>+</sup> T cell response (measured in <a href="htt...
<p>The magnitude of the CD8+ T cells expressing at least one cytokine among IL-2, TNF-α and IFN-γ is...
<p>Cells from each animal were stimulated with each different peptide pool for 6°C in the presence o...
<p>A. Geometric mean CS-specific CD4<sup>+</sup> T cells producing IFN-γ by ELISpot. Comparisons bet...
<p>The response patterns are color-coded by the number of positive functions. The x-axis contains th...
<p>PBMC from all study subjects were stimulated with peptide pools, selected for positive responses ...
<p>(<b>A</b>) Representative dot plots of gating strategy used and cytokine responses detected using...
<p>PBMCs isolated 2 weeks after the fourth immunization were stimulated <i>in vitro</i> with a SIVpo...
<p>Splenocytes from mice immunized as in <a href="http://www.plosone.org/article/info:doi/10.1371/jo...
<p><b>A.</b> Distribution of cytokines produced by multifunctional or monofunctional T cells. The pe...
<p>(A) The total magnitude of the PBMC CD8 T cell response as measured by IFN-γ ELISPOT assays using...