<p>A 96-well plate was coated with 4 μg/well of Z-α1AT and incubated for 16 h with 100 μM of various compounds and 38.4 μM of bPEG-peptide. The black arrow indicates the compound that corresponds to S-(4-nitrobenzyl)-6-thioguanosine and gives an inhibition effect of 67 ± 2% and. The error bars are the standard deviation of three individual experiments.</p
<p>(<b>A</b>) Inhibition potencies of the candidate compounds. The magnitudes of inhibition by compo...
<p>(A) Z' factors for replicate LOPAC experiments ± detergent. (B–C) Comparison of duplicate runs of...
<p>(A) In a 384-well plate, 192 wells were used as a negative control (buffer only), represented by ...
<p>(A) Dose-response curves were assayed for various concentrations of (●) S-(4-nitrobenzyl)-6-thiog...
<p>Plot of percent inhibition for duplicate screen of the 1280 LOPAC compounds. LOPAC compounds (blu...
<p>(<b>A</b>) Inhibition by Mg·AMP with Mg·ADP as variable substrate. Measurements were assayed at f...
<p>(A) <i>i</i>, The IC<sub>50</sub> inhibition curves of the tyrphostin analogues identified from t...
<p>The protein was incubated with (●) or without (■) 100 μM of S-(4-nitrobenzyl)-6-thioguanosine for...
<p>(A) Single point hit confirmation assay was an analysis of each of the initial hits in a 384-well...
<p>Scatter plot of screening data for a small library of known bioactive small molecules using the P...
<p>The LOPAC was screened to assess the degree to which Promega’s ADP-Glo Max assay can be used to m...
<p>(A) Purified GSTP1-1 (20 pmoles) incubated with authentic HOSCN (10, 1, and 0.5 µM). (B) Purified...
<p>Inhibition data from 16 small molecules selected by virtual screening. Antagonists shown to inhib...
<p>(A) Chemical structure of Compound <b>1</b>. (B) Dose-dependent inhibition of Compound <b>1</b> i...
[a]Assays were performed in duplicate (errors were less than 5%) with nitrocefin (114.28 μM, Km 36 μ...
<p>(<b>A</b>) Inhibition potencies of the candidate compounds. The magnitudes of inhibition by compo...
<p>(A) Z' factors for replicate LOPAC experiments ± detergent. (B–C) Comparison of duplicate runs of...
<p>(A) In a 384-well plate, 192 wells were used as a negative control (buffer only), represented by ...
<p>(A) Dose-response curves were assayed for various concentrations of (●) S-(4-nitrobenzyl)-6-thiog...
<p>Plot of percent inhibition for duplicate screen of the 1280 LOPAC compounds. LOPAC compounds (blu...
<p>(<b>A</b>) Inhibition by Mg·AMP with Mg·ADP as variable substrate. Measurements were assayed at f...
<p>(A) <i>i</i>, The IC<sub>50</sub> inhibition curves of the tyrphostin analogues identified from t...
<p>The protein was incubated with (●) or without (■) 100 μM of S-(4-nitrobenzyl)-6-thioguanosine for...
<p>(A) Single point hit confirmation assay was an analysis of each of the initial hits in a 384-well...
<p>Scatter plot of screening data for a small library of known bioactive small molecules using the P...
<p>The LOPAC was screened to assess the degree to which Promega’s ADP-Glo Max assay can be used to m...
<p>(A) Purified GSTP1-1 (20 pmoles) incubated with authentic HOSCN (10, 1, and 0.5 µM). (B) Purified...
<p>Inhibition data from 16 small molecules selected by virtual screening. Antagonists shown to inhib...
<p>(A) Chemical structure of Compound <b>1</b>. (B) Dose-dependent inhibition of Compound <b>1</b> i...
[a]Assays were performed in duplicate (errors were less than 5%) with nitrocefin (114.28 μM, Km 36 μ...
<p>(<b>A</b>) Inhibition potencies of the candidate compounds. The magnitudes of inhibition by compo...
<p>(A) Z' factors for replicate LOPAC experiments ± detergent. (B–C) Comparison of duplicate runs of...
<p>(A) In a 384-well plate, 192 wells were used as a negative control (buffer only), represented by ...