Silencing the expression of Bag-1 could inhibit the proliferation of gallbladder carcinoma cells.

<p>(A) Immunoblots were performed to analyze Bag-1, BCL-2, Bax, and cleavage of caspase-3 expression in Bag-1 siRNA-transfected OCUG-1 and NOZ cells. (B and C) MTT assay was used to measure cell proliferative capacity in gallbladder carcinoma cells treated with the control siRNA or Bag-1 siRNA. (D) Gallbladder carcinoma cells transduced with miR-138 compared with the control vector were subjected to Western blot analysis with the indicated antibodies. Error bars represented the SD from three independent trials. *<i>P</i><0.05; **<i>P</i><0.01.