Effects of PPAR-β/-γ antagonists on nifedipine-mediated NO/cyclic-GMP formation and CD40L/sCD40L cascade.

<p>Platelets were incubated with various drugs, followed by addition of collagen. The levels of NOx (A) cyclic GMP formation (B) platelet surface CD40L expression (C) and sCD40L concentrations (D) were determined. Date were expressed as means ± SEM (<i>n</i> = 5). ^**<i>p</i> < 0.01, ^***<i>p</i> < 0.001 compared with collagen alone group; ⁺<i>p</i> < 0.05, ⁺⁺<i>p</i> < 0.01, ⁺⁺⁺<i>p</i> < 0.001 compared with respective collagen+nifedipine-treated group.