Effects of PPAR-β/-γ antagonists on nifedipine-mediated MMP2 activity.

<p>Platelets were treated with nifedipine (5 μ M), or nifedipine combined with various drugs for 3 min, followed by addition of collagen for 6 min. The MMP-2 expression (A) and MMP-2 activity (B) were determined. Date were expressed as means ± SEM (<i>n</i> = 5). ^***<i>p</i> < 0.001 compared with collagen alone group; ⁺⁺<i>p</i> < 0.01, ⁺⁺⁺<i>p</i> < 0.001 compared with respective collagen+nifedipine-treated group.