Metal-Free Oxidative Spirocyclization of Alkynes with Sulfonylhydrazides Leading to 3‑Sulfonated Azaspiro[4,5]trienones

A novel and direct oxidative spirocyclization of arylpropiolamides with sulfonylhydrazides leading to 3-sulfonated azaspiro­[4,5]­trienones has been developed under metal-free conditions. The reaction is performed in a tandem manner constituted by the sequential sulfonylation of alkynes, <i>ipso</i>-carbocyclization, dearomatization, hydration, and oxidation processes, providing a convenient and efficient approach to various sulfonated azaspiro­[4,5] trienones of biological importance