IgG and T lymphocyte subsets expression in different outcome groups of ITP patients.

<p>(A) IgG levels in healthy controls, respond group (CR+R) and non-respond group (NR) were 11.15±4.61g/L, 22.07±4.65 g/L, 19.54±4.28 g/L, respectively. IgG expression in both respond and non-respond groups were remarkably higher than that in controls (P<0.001), but there was no significant difference between the respond group and the non-respond group. CD3⁺ cell percentage in respond group was 59.00±12.08%, which was lower than that in controls (66.98±6.86%, P<0.05). CD19⁺ cell percentage in respond group was 17.88±9.45%, which was higher than that in controls (12.47±2.19%, P<0.05). Increased CD8⁺ cell expression was observed in non-respond group (32.42±8.07%, P<0.01) compared with that in controls (22.99±3.24%) and that in respond group (24.13±7.83%). There were no remarkable differences in CD2⁺, CD4⁺ and NK cell expression among the three groups. (B) A significant reduction in CD4⁺/CD8⁺ cell ratio was seen in non-respond group (0.98±0.50) compared with that in controls (1.56±0.29, P<0.001) and that in respond group (1.42±0.61, P<0.01).