<i>c</i>SiO₂ elicits perivascular and peribronchiolar lymphocytic infiltration in lungs of NZBWF1 and C57Bl/6 mice.

<p>Representative light photomicrographs of H&E stained lung sections from NZBWF1 mice exposed to vehicle (A), 0.25 mg <i>c</i>SiO₂ (B), or 1.0 mg <i>c</i>SiO₂ (C) and C57Bl/6 mice given vehicle (D), or 1.0mg <i>c</i>SiO₂ (E). Br = bronchiole, bv = bronchial vasculature, ap = alveolar parenchyma. Black arrows indicate lymphocytic infiltration in perivascular and peribronchial regions. Lymphocytic infiltration was semi-quantitatively graded as described in the Materials and Methods (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125481#pone.0125481.t001" target="_blank">Table 1</a>).