Distribution of risk scores and patient survival duration.

<p>Analysis of risk scores, OS, and mRNA expression in the CGGA cohort (A) and the TCGA cohort (B), including (Top) signature risk score distribution and (Middle) patient survival status and duration. A heat map showing expression of the six genes in both the high-risk and low-risk groups (Bottom); rows represent corresponding genes, and columns indicate corresponding patients. The black dotted lines in the middle of each graph (A, B) represent the gene signature cutoff (median risk score). Principal component analyses (C) of the CGGA dataset using the six genes. Graph of the first 3 principal components shows excellent separation between low-risk (pink) and high-risk (blue) groups. PCA1, PCA2, and PCA3 represent the top three dimensions of genes showing differential expression among these preimplantation blastomeres, which account for 41.2%, 17.6%, and 15.6% of the expressed genes, respectively.