Novel miRNA candidates.

<p>(a) Sequence alignment of novel miRNA candidates with known miRNAs of other species. *: conserved nucleotide. bta: <i>Bos taurus</i>. cfa: <i>Canis familiaris</i>. gga: <i>Gallus gallus</i>. hsa: <i>Homo sapiens</i>. mdo: <i>Monodelphis domestica</i>. mml: <i>Macaca mulatta</i>. mmu: <i>Mus musculus</i>. ptr: <i>Pan troglodytes</i>. rno: <i>Rattus norvegicus</i>. xtr: <i>Xenopus tropicalis</i>. (b) Secondary structures of putative precursor hairpins corresponding to six novel miRNA candidates identified in this study. One (seq-6713_x208) of these novel miRNAs were found to be up-regulated in late-gestational fetal KCs, whereas the other five miRNAs were down-regulated (see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0126087#pone.0126087.s007" target="_blank">S7 Table</a>).