Signature OTUs that define periodontitis clusters A and B (hierarchical).

<p>Graph shows OTUs with a statistically significant difference in relative abundance between hierarchical clusters A and B. Bars represent the median and range of relative abundances for each OTU. OTUs increased in Cluster A appear in the top, while OTUs increased in cluster B appear in the bottom. OTUs were labeled according to their association with health or periodontitis considering data from Abusleme et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127077#pone.0127077.ref006" target="_blank">6</a>], Perez-Chaparro et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127077#pone.0127077.ref031" target="_blank">31</a>] and a comparison of our periodontitis samples with HMP healthy subjects (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127077#pone.0127077.s004" target="_blank">S4 Fig</a>). Taxa were classified as P (periodontitis), H (health) and C (core species), according to at least one study. If a disagreement existed between studies, taxa were labeled under more than one category.