<p>(A) The effect of NPY on basal glucose consumption of 3T3-L1 adipocytes. The differentiated 3T3-L1 adipocytes were incubated with DMEM containing 0.2% BSA for 12 h and then treated with 1–100 nM NPY for 12 h or 100 nM insulin (INS) for 2 h to detect basal glucose consumption. Insulin was used as a positive control. The amount of glucose that disappeared in the medium was determined as the amount of glucose consumption. (B) The effect of Y1 receptor antagonist BIBP-3226 on insulin-stimulated glucose consumption in 3T3-L1 adipocytes treated with NPY. Cells were pre-treated with 1–100 μM BIBP-3226 for 8 h, then subsequently treated with 100 nM NPY for 12 h with 100 nM insulin for 2 h to detect insulin-stimulated glucose consumption. (C) The...
Glucose uptake by peripheral tissues such as skeletal muscles and adipocytes is important in the mai...
<p>Eight weeks after dietary and lentiviral intervention, insulin resistance was evaluated. (A) Aver...
<p><b>a</b>, Chemical structure of P1736. <b>b</b>, Insulin stimulated glucose uptake in normal a...
<p>The differentiated 3T3-L1 adipocytes were pretreated with 100 μM L-152,804 or 100 μM BIBP3226 for...
<p>(<b>a</b>) 3T3-L1 adipocytes were treated with U18666a for indicated periods of time before radio...
Objectives: Loss of functional β-cell mass is a key factor contributing to poor glycemic control in ...
AbstractIn order to characterize neuropeptide Y (NPY) receptors present in human adipocytes, we used...
<p>NPC1 was inhibited in 3T3-L1 adipocytes through treatment with U18666a or through siRNA-mediated ...
Peptide YY3-36 (PYY3-36) is released by the gut in response to nutrient ingestion. It modulates the ...
Recently, we have shown that neuropeptide Y (NPY) is produced and upregulated in visceral adipose ti...
<div><p>Glucose uptake by peripheral tissues such as skeletal muscles and adipocytes is important in...
Objective: PPAR alpha/gamma dual agonists have been in clinical development for the treatment of met...
<p>(A-C) Differentiated 3T3-L1 cells were treated with insulin (0.5–5 µg/ml) or TNF-α (10–100 ng/ml)...
<p>Neuropeptide Y (NPY) plays an important role in the regulation of energy homeostasis in the level...
Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY...
Glucose uptake by peripheral tissues such as skeletal muscles and adipocytes is important in the mai...
<p>Eight weeks after dietary and lentiviral intervention, insulin resistance was evaluated. (A) Aver...
<p><b>a</b>, Chemical structure of P1736. <b>b</b>, Insulin stimulated glucose uptake in normal a...
<p>The differentiated 3T3-L1 adipocytes were pretreated with 100 μM L-152,804 or 100 μM BIBP3226 for...
<p>(<b>a</b>) 3T3-L1 adipocytes were treated with U18666a for indicated periods of time before radio...
Objectives: Loss of functional β-cell mass is a key factor contributing to poor glycemic control in ...
AbstractIn order to characterize neuropeptide Y (NPY) receptors present in human adipocytes, we used...
<p>NPC1 was inhibited in 3T3-L1 adipocytes through treatment with U18666a or through siRNA-mediated ...
Peptide YY3-36 (PYY3-36) is released by the gut in response to nutrient ingestion. It modulates the ...
Recently, we have shown that neuropeptide Y (NPY) is produced and upregulated in visceral adipose ti...
<div><p>Glucose uptake by peripheral tissues such as skeletal muscles and adipocytes is important in...
Objective: PPAR alpha/gamma dual agonists have been in clinical development for the treatment of met...
<p>(A-C) Differentiated 3T3-L1 cells were treated with insulin (0.5–5 µg/ml) or TNF-α (10–100 ng/ml)...
<p>Neuropeptide Y (NPY) plays an important role in the regulation of energy homeostasis in the level...
Enzymatically stable and specific neuropeptide Y1 receptor (NPYR1) agonists, such as sea lamprey PYY...
Glucose uptake by peripheral tissues such as skeletal muscles and adipocytes is important in the mai...
<p>Eight weeks after dietary and lentiviral intervention, insulin resistance was evaluated. (A) Aver...
<p><b>a</b>, Chemical structure of P1736. <b>b</b>, Insulin stimulated glucose uptake in normal a...