Dose-dependent blockage of bacteremia and meningitis.

<p>C57BL/6J mice (10days) were injected (i.p.) twice with various concentrations (0–20 mg/kg) of MEM at 12 h before and at the time of bacteria inoculation (2×10⁵ CFU of E44). Bacteremia and meningitis in mice were evaluated at 18h after infection. The numbers of surviving bacteria in blood (<b>A</b>) and CSF (<b>B</b>) were determined. Neonatal mice were divided into 5 groups (5 pups/group). All values represent the means of determinations. Each experiment was performed three times. *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001.