Representation of the docking models of the dihydropyrimidinase complex from PatchDock.

<p>(A) The binding mode of dihydropyrimidinase to dihydromyricetin. Dihydromyricetin interacted with I95 (light pink), S289 (limon), and D316 (yellow) of dihydropyrimidinase, in which S289 and D316 were found to be crucial for the catalytic activity of dihydropyrimidinase. (B) The binding mode of dihydropyrimidinase to myricetin. Myricetin interacted with N157 (light pink), Q194 (light pink), R212 (light pink), and N337 (limon), in which N337 was found to be crucial for the catalytic activity of dihydropyrimidinase.