<p>A-D: Activity of the network nodes as functions of Meth concentration in the blood after three doses of SB-334867: 0 (Veh), 10 and 30 mg/kg using best fit parameters. E: Time courses of the Meth concentration after different doses of Meth (1, 5 and 10 mg/kg) as generated by the model.</p
<p>The plasma concentration-time profiles of Compound 1 after intravenous administration at 180 mg/k...
A simple model simulating the kinetics of drug metabolism inhibition interaction is investigated. Th...
<p>The plasma concentration-time profiles of Compound 1 after oral administration at 45, 180 and 720...
<p>Experimental data shown by open circles (average temperature); error bars represent standard devi...
<p>Meth is injected at <i>t</i> = 0 min (dashed lines). SB is injected 30 min prior to Meth. <b>A-D<...
Methamphetamine (Meth) can evoke extreme hyperthermia, which correlates with neurotoxicity and death...
<p>A-B: Statistical ensembles of parameters (amplitude of stress, and Meth-sensitivities of three Me...
<p>(B-F) Overlay of the experimental data (black curve) with curve(s) fit to a single or double expo...
Pharmacokinetics is the study of how drugs are absorbed and distributed in the body and is used by p...
<p>(A) The spectral binding was performed at varying concentrations of methamphetamine from 1 μM to ...
<p>Data are mean (S.E.M.). Neurotransmitter and metabolite levels are expressed in ng/g wet tissue, ...
Orexinergic neurotransmission is involved in mediating temperature responses to methamphetamine (Met...
Orexinergic neurotransmission is involved in mediating temperature responses to methamphetamine (Met...
ysis of the basic model for target mediated drug disposition (TMDD). Assuming high affinity of ligan...
<p>Dopamine uptake by mouse DAT (A), norepinephrine uptake by mouse NET (B), and serotonin uptake by...
<p>The plasma concentration-time profiles of Compound 1 after intravenous administration at 180 mg/k...
A simple model simulating the kinetics of drug metabolism inhibition interaction is investigated. Th...
<p>The plasma concentration-time profiles of Compound 1 after oral administration at 45, 180 and 720...
<p>Experimental data shown by open circles (average temperature); error bars represent standard devi...
<p>Meth is injected at <i>t</i> = 0 min (dashed lines). SB is injected 30 min prior to Meth. <b>A-D<...
Methamphetamine (Meth) can evoke extreme hyperthermia, which correlates with neurotoxicity and death...
<p>A-B: Statistical ensembles of parameters (amplitude of stress, and Meth-sensitivities of three Me...
<p>(B-F) Overlay of the experimental data (black curve) with curve(s) fit to a single or double expo...
Pharmacokinetics is the study of how drugs are absorbed and distributed in the body and is used by p...
<p>(A) The spectral binding was performed at varying concentrations of methamphetamine from 1 μM to ...
<p>Data are mean (S.E.M.). Neurotransmitter and metabolite levels are expressed in ng/g wet tissue, ...
Orexinergic neurotransmission is involved in mediating temperature responses to methamphetamine (Met...
Orexinergic neurotransmission is involved in mediating temperature responses to methamphetamine (Met...
ysis of the basic model for target mediated drug disposition (TMDD). Assuming high affinity of ligan...
<p>Dopamine uptake by mouse DAT (A), norepinephrine uptake by mouse NET (B), and serotonin uptake by...
<p>The plasma concentration-time profiles of Compound 1 after intravenous administration at 180 mg/k...
A simple model simulating the kinetics of drug metabolism inhibition interaction is investigated. Th...
<p>The plasma concentration-time profiles of Compound 1 after oral administration at 45, 180 and 720...