Mitochondrial quality control processes.

<p>The model accounts for the processes of mitochondrial turnover (mitogenesis and mitophagy) and mitochondrial fusion-fission. The box highlights the selectivity of mitochondrial fusion and mitophagy. Mitochondria with a high fraction of mutant mtDNA and consequently lowered membrane potential (Δψ) are less likely to fuse with other mitochondria and preferentially removed by mitophagy.