JNK activation by PDTC promotes c-Jun phosphorylation.

<p>A; Activation of JNK phosphorylation by PDTC is abolished by SP600125. U937 cells were pre-incubated with 10 μM SP600125 for 1 h, and then treated with 1 μM PDTC for 20 min prior cell lyses. B; PDTC-induced c-Jun activation is dependent on JNK phosphorylation in U937 cells. The data shown are means ± SD from 4 independent experiments.