Simulations of epithelial morphogenesis in non-proliferative and proliferative context.

<p>Left pictures represent numerical objects at 99% coverage of the sphere surface (color-coded as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0126341#pone.0126341.g007" target="_blank">Fig 7</a>, with blue lines indicating the axis of division). Apoptotic cells presented a twisted membrane and a loss of internal grains. Respective right skeleton pictures illustrate the 3D perspective. A-B: accretion-driven morphogenesis at two different organization rates (A, low rate; B, high rate, see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0126341#pone.0126341.t001" target="_blank">Table 1</a>). C-E: morphogenesis in a proliferative context (7% mitotic cells at any time) with different mitosis/apoptosis ratios: 1/3 (C); 1/5 (D); no apoptosis (E). The number of cells covering the surface of the sphere is indicated in each case with the standard deviation from n number of simulations. All standard errors for histograms were lower than 0.09.