CHIP ubiquitination of Hsc70 (A) and Hsp70 (B) is wide-spread but largely focused on the C-terminal half of the protein.

<p>Homology models based on the structure of DnaK (PDB ID 2KHO) were created using SWISS-MODEL, and are here used to map the sequence coverage and ubiquitination sites found by mass spectrometry proteomics. Observed regions are colored in red, with unobserved regions in grey. All lysine side-chains are explicitly shown with confirmed ubiquitination sites highlighted in yellow.