Photomicrograph of mice liver sections (Masson’s Trichrome staining) ×100.

<p>(A) Control mice liver shows normal cellular integrity with no fibrosis. (B) Iron-intoxicated (iron dextran, 100 mg/kg b.w.) liver section with elongated fibrous septa and accumulation of collagen (Blue). (C) Liver section treated with iron dextran + 50 mg/kg b.w. DBME shows slight fibrosis. (D) Liver section treated with iron dextran + 100 mg/kg b.w. DBME shows improved histology. (E) Liver section treated with iron dextran + 200 mg/kg b.w. DBME. (F) Liver section treated with iron dextran + 20 mg/kg b.w. desirox shows nearly negligible accumulation of collagen and healthy liver. S100 and S200 show reduced collagen deposition, fibrous septum and necrotic cells in periportal veins indicating a trend of restoration of normal cellular integrity.