<p>All models were adjusted for age and gender. NMR = nicotine metabolite ratio.</p><p>The <i>CHRNA5-A3-B4</i> haplotype was defined by rs16969968 and rs588765.</p><p>* Cotinine is a part of NMR, and cotinine levels are not directly comparable in people with different NMR [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128109#pone.0128109.ref048" target="_blank">48</a>], thus NMR was not included in the cotinine analysis.</p><p>The association between <i>CHRNA5-A3-B4</i> rs16969968_rs588765 haplotype and baseline smoking behaviors in the screened population (N = 1026).</p
Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3'hydroxycotinine. ...
Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk for smok...
The nicotine metabolite ratio (NMR; 3-hydroxycotinine/cotinine) is an index of CYP2A6 activity. CYP2...
<p>(a) <i>CHRNA5-A3-B4</i> haplotype was not associated with smoking abstinence in smokers treated w...
Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are alt...
<div><p>The Nicotine Metabolite Ratio (NMR, ratio of <i>trans</i>-3’-hydroxycotinine and cotinine), ...
Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3′hydroxycotinine. ...
Tobacco use is the leading preventable cause of death worldwide. In order to address this epidemic, ...
We assessed whether smoking behavior was associated with nine polymorphisms in genes coding for the ...
<p>(a) The ‘A’ allele of rs16969968 was significantly associated with higher cotinine levels (10.2% ...
The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously ...
Genome-wide association studies (GWAS) of complex behavioural phenotypes such as cigarette smoking t...
Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibl...
<p>(a) Rs578776 was not associated with smoking abstinence in smokers treated with placebo. Adjustin...
Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibl...
Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3'hydroxycotinine. ...
Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk for smok...
The nicotine metabolite ratio (NMR; 3-hydroxycotinine/cotinine) is an index of CYP2A6 activity. CYP2...
<p>(a) <i>CHRNA5-A3-B4</i> haplotype was not associated with smoking abstinence in smokers treated w...
Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are alt...
<div><p>The Nicotine Metabolite Ratio (NMR, ratio of <i>trans</i>-3’-hydroxycotinine and cotinine), ...
Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3′hydroxycotinine. ...
Tobacco use is the leading preventable cause of death worldwide. In order to address this epidemic, ...
We assessed whether smoking behavior was associated with nine polymorphisms in genes coding for the ...
<p>(a) The ‘A’ allele of rs16969968 was significantly associated with higher cotinine levels (10.2% ...
The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously ...
Genome-wide association studies (GWAS) of complex behavioural phenotypes such as cigarette smoking t...
Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibl...
<p>(a) Rs578776 was not associated with smoking abstinence in smokers treated with placebo. Adjustin...
Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibl...
Nicotine is inactivated by the polymorphic CYP2A6 enzyme to cotinine and then to 3'hydroxycotinine. ...
Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk for smok...
The nicotine metabolite ratio (NMR; 3-hydroxycotinine/cotinine) is an index of CYP2A6 activity. CYP2...