Kaplan-Meir survival curve of mice infected with <i>P</i>. <i>berghei</i> parasites lacking or overexpressing the <i>pbggcs</i> gene.

<p>Mice infected with wild type (green, n = 15), <i>pbggcs-ko</i> (red, n = 10) or <i>pbggcs-oe</i> parasites (blue, n = 10) were treated with intramuscular doses of 20 mg/kg of DHA beginning 1 hr post infection, and daily for four consecutive days. Mice survival was monitored after the 4^th day of DHA treatment (day 0). Mice mortality is defined as mice humanly euthanized due to distress caused by severe malaria. Survival of mice infected with wild type parasites was comparable to the survival of mice infected with <i>pbggcs-oe</i> parasites and rapidly declined after treatment with DHA. In contrast, 90% of the mice infected with <i>pbggcs-ko</i> parasites survived after the DHA treatment. Asterisk denote significant changes in survival as determined by a Log-rank (Mantel-Cox) Test (* = P<0.0001).