Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction - Fig 8

<p><b>(A) Receiver operator characteristic (ROC) analysis for serum metabolites, cardiac peptides, and combined serum metabolites and BNP.</b> Logistic regression (LR) was performed to find the most parsimonious model to discriminate HFpEF from HFrEF patients using the minimum number of metabolites and/or cardiac peptides. 2-hydroxybutyrate, octadecenoylcarnitine (C18:1), hydroxyprionylcarnitine (C3-OH), and sphingomyelin C24:1 were used in the metabolites-only panel. While acetate, 2-hydroxybutyrate, pimelyl carnitine, and phosphatidyl choline diacyl C40:4 were used for the combined metabolites and NT-proBNP panel. <b>(B–E) Quantification of the metabolites used to derive the LR equation of the combined metabolites and NT-proBNP model.</b> Data are presented as means ± SD. The dashed line represents the metabolite concentration in control subjects. * p < 0.05 compared to the HFpEF group.