Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction - Fig 6

<p><b>(A) Receiver operator characteristic (ROC) analysis for serum metabolites, cardiac peptides, and combined serum metabolites and NT-proBNP.</b> Logistic regression (LR) was performed to find the most parsimonious model to discriminate HFrEF patients from control subjects using the minimum number of metabolites and/or cardiac peptides. Creatinine, carnitine, acetoacetate, lysophosphatidylcholine acyl C18:2, 2-hydroxybutyrate, and lysophosphatidylcholine acyl C20:4 were used in the metabolites-only panel. While acetoacetate was used for the combined metabolites and NT-proBNP panel. <b>(B) Quantification of acetoacetate which was used to derive the LR equation of the combined metabolites and NT-proBNP model.</b> Data are presented as means ± SD. * p < 0.1 compared to the control group.