The synaptic depression-facilitation model accounts for bursting reverberation.

<p><i>(A)</i> Evoked bursts generated in a microculture hippocampal neurons, with a single action potential evoked alternately at 5 and 35 seconds intervals, showing a reduction in burst duration when the bursts are generated at the short interval. <i>(B)</i> Following the experimental protocol, we simulated with <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124694#pone.0124694.e001" target="_blank">Eq 1</a> and parameters of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124694#pone.0124694.t001" target="_blank">Table 1</a> the mean firing rate response, plotted as a function of time. The corresponding facilitation and depression variables show the level of neuronal activity underlying the overall dynamics. <i>(C)</i> Plot of the product <i>xy</i>, which accounts for the total synaptic modulation, as a function of time. <i>(D)</i> Burst durations at 35 seconds and 5 seconds intervals. We compare the burst durations from experimental data (n = 20) with numerical simulations of the model <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124694#pone.0124694.e001" target="_blank">Eq 1</a>.