Schematic representation of collagen orientation evolution with time in low (A-C) and high (D-F) rectangular TE strips.

<p>The collagen orientation changes by culture time. First, the fibers were randomly oriented. By extending culture time, fibers aligned in the constrained direction in the high aspect ratio strips and in the oblique direction in low aspect ratio strips. By culturing for a longer time, the fibers aligned in the oblique direction in both configurations.