p53 signalling and senescence after irradiation.

<p>Comparison between single cell measurements of p53 dynamics after irradiation and integrated model simulations (experimental data from [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004246#pcbi.1004246.ref041" target="_blank">41</a>]) for A) number of p53 pulses observed in the first 16 h after irradiation with 0 Gy (black), 2.5 Gy (blue) or 10 Gy (green). B) pulse width and C) normalized pulse amplitude. D) p53 response to 5 Gy irradiation with and without Nutlin-3 inhibition; representative single runs (top), population average (bottom). E) Measurement [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004246#pcbi.1004246.ref013" target="_blank">13</a>] and simulation of senescence after irradiation with or without Nutlin-3 inhibition. Data are presented as mean ± 95% confidence interval (A,D) or mean ± SE (B,C). n ≥ 100 cells per experiment [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004246#pcbi.1004246.ref013" target="_blank">13</a>] and n ≈ 200 simulations.