<p>After induction of mucous metaplasia with IL-13, tracheas from WT and P2Y2R null mice on the same 129S6 background were equilibrated under continuous perfusion, and baseline mucin secretion was then determined under stopped-flow and following restoration of continuous perfusion, from subunit ELISAs, per <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127267#pone.0127267.g010" target="_blank">Fig 10</a> (* <i>p</i> < 0.05, n = 3 or 4).</p
<p>After 60 min of perfusion under baseline conditions, isolated mouse lungs were perfused for anoth...
<p>(A) Representative immunohistochemistry of the smooth muscle myosin light chain 2 expression in a...
<p>(A) LPS infusion increased the influx of MPO-positive cells into jejunal tissue of control and <i...
<p><b><i>A</i>. <i>AB/PAS-stained sections of intrapulmonary bronchus</i></b>, illustrating the degr...
<p>After 60 min of perfusion under baseline conditions, isolated mouse lungs were perfused for anoth...
<p>Number of perfused vessels was determined with SDF-imaging. Fewer vessels per villus were perfuse...
<p>After 60 min of perfusion under baseline conditions, isolated mouse lungs were perfused for anoth...
<p>WT C57BL/6 and OPN-/- mice were intranasally infection with a high dose of mucogenic rA2-L19F (1×...
<p>(A) Images of mucus bubbles in the tracheas of wild type littermates, PAR-2 knock out and targete...
Compared with WT-Con and TG-Con mice, WT-LPS mice showed a marked increase in MPO activity in all fi...
<p>Mucus isolated from mice on day 21 of acute (A, B) and chronic (C, D) infection was treated with ...
<p>Muc18 WT (n = 9) and KO (n = 13) were intranasally infected with HRV-1B or PBS as a control (WT: ...
<p>Mucus penetration, mucus layering and goblet cell filling in the colon of mice after 24 and 48 h ...
<p>A) Whole stimulated saliva produced by A20<sup>-/-</sup> mice and WT littermate controls. <i>n</i...
<p>Mice were challenged with LPS by one single i.p. injection (2mg/kg) or two consecutive injections...
<p>After 60 min of perfusion under baseline conditions, isolated mouse lungs were perfused for anoth...
<p>(A) Representative immunohistochemistry of the smooth muscle myosin light chain 2 expression in a...
<p>(A) LPS infusion increased the influx of MPO-positive cells into jejunal tissue of control and <i...
<p><b><i>A</i>. <i>AB/PAS-stained sections of intrapulmonary bronchus</i></b>, illustrating the degr...
<p>After 60 min of perfusion under baseline conditions, isolated mouse lungs were perfused for anoth...
<p>Number of perfused vessels was determined with SDF-imaging. Fewer vessels per villus were perfuse...
<p>After 60 min of perfusion under baseline conditions, isolated mouse lungs were perfused for anoth...
<p>WT C57BL/6 and OPN-/- mice were intranasally infection with a high dose of mucogenic rA2-L19F (1×...
<p>(A) Images of mucus bubbles in the tracheas of wild type littermates, PAR-2 knock out and targete...
Compared with WT-Con and TG-Con mice, WT-LPS mice showed a marked increase in MPO activity in all fi...
<p>Mucus isolated from mice on day 21 of acute (A, B) and chronic (C, D) infection was treated with ...
<p>Muc18 WT (n = 9) and KO (n = 13) were intranasally infected with HRV-1B or PBS as a control (WT: ...
<p>Mucus penetration, mucus layering and goblet cell filling in the colon of mice after 24 and 48 h ...
<p>A) Whole stimulated saliva produced by A20<sup>-/-</sup> mice and WT littermate controls. <i>n</i...
<p>Mice were challenged with LPS by one single i.p. injection (2mg/kg) or two consecutive injections...
<p>After 60 min of perfusion under baseline conditions, isolated mouse lungs were perfused for anoth...
<p>(A) Representative immunohistochemistry of the smooth muscle myosin light chain 2 expression in a...
<p>(A) LPS infusion increased the influx of MPO-positive cells into jejunal tissue of control and <i...