The flexible regions and mental retardation mutation in the context of human full length cereblon.

<p>At the top, interaction partner DDB1 is represented by a sphere. The thalidomide binding domain is in green (rigid core), yellow (flexible regions) and red (deleted C-terminal part in the MsCI4^WWK/FFX mutant). The exact boundaries of the segments are defined in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128342#pone.0128342.g002" target="_blank">Fig 2</a>. The N-terminal extension of cereblon is in brown, the remainder of the protein grey.